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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735280
Species: Mus musculus
RGD Object: Gene
Symbol: Rps6
Name: ribosomal protein S6
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rps6decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of RPS6 mRNAPMID:33221593
Rps6affects expressionISORps6 (Rattus norvegicus)6480464CTDbisphenol A affects the expression of RPS6 mRNAPMID:25181051
Rps6affects expressionISORPS6 (Homo sapiens)6480464CTDbisphenol A affects the expression of RPS6 mRNAPMID:30903817
Rps6decreases expressionISORps6 (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of RPS6 mRNAPMID:32145629
Rps6decreases expressionISORPS6 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of RPS6 mRNA; bisphenol A results in decreased expression of RPS6 proteinPMID:21890461 PMID:31675489 PMID:34186270 PMID:37567409
Rps6increases expressionISORPS6 (Homo sapiens)6480464CTDbisphenol A results in increased expression of RPS6 proteinPMID:21890461
Rps6increases phosphorylationISORPS6 (Homo sapiens)6480464CTDbisphenol A results in increased phosphorylation of RPS6 proteinPMID:21890461
Rps6multiple interactionsISORps6 (Rattus norvegicus)6480464CTD[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of RPS6 mRNAPMID:36041667
Rps6multiple interactionsISORPS6 (Homo sapiens)6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of RPS6 mRNA; bisphenol A results in increased phosphorylation of and results in increased expression of RPS6 protein; Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of and results in increased expression of RPS6 protein]PMID:23222814 PMID:28628672
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