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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734184
Species: Mus musculus
RGD Object: Gene
Symbol: Flt1
Name: FMS-like tyrosine kinase 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Flt1increases expressionEXP 6480464CTDbisphenol A results in increased expression of FLT1 mRNA; bisphenol A results in increased expression of FLT1 proteinPMID:30303745 PMID:30951980
Flt1multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Tretinoin] results in decreased expression of FLT1 mRNAPMID:30951980
Flt1decreases expressionISOFlt1 (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of FLT1 mRNAPMID:25181051 PMID:30816183 PMID:34947998
Flt1decreases expressionISOFLT1 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of FLT1 proteinPMID:31675489
Flt1increases expressionISOFLT1 (Homo sapiens)6480464CTDbisphenol A results in increased expression of FLT1 mRNAPMID:31715268
Flt1multiple interactionsISOFLT1 (Homo sapiens)6480464CTD[bisphenol A co-treated with Fulvestrant] results in increased methylation of FLT1 genePMID:31601247
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