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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733969
Species: Mus musculus
RGD Object: Gene
Symbol: Ikbkb
Name: inhibitor of kappaB kinase beta
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ikbkbincreases expressionISOIkbkb (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of IKBKB mRNAPMID:17010207 PMID:25181051
Ikbkbincreases expressionISOIKBKB (Homo sapiens)6480464CTDbisphenol A results in increased expression of IKBKB mRNA; bisphenol A results in increased expression of IKBKB protein modified formPMID:29793316 PMID:33670352
Ikbkbmultiple interactionsISOIKBKB (Homo sapiens)6480464CTD[IKBKB protein co-treated with bisphenol A] results in decreased expression of APOA1 mRNA; Curcumin inhibits the reaction [bisphenol A results in increased expression of IKBKB protein modified form]PMID:29793316 PMID:31842455
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