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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732982
Species: Mus musculus
RGD Object: Gene
Symbol: Tpp1
Name: tripeptidyl peptidase I
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tpp1decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of TPP1 mRNAPMID:32156529
Tpp1decreases methylationEXP 6480464CTDbisphenol A results in decreased methylation of TPP1 promoterPMID:27312807
Tpp1increases expressionEXP 6480464CTDbisphenol A results in increased expression of TPP1 mRNAPMID:26063408 PMID:34585602
Tpp1affects expressionISOTPP1 (Homo sapiens)6480464CTDbisphenol A affects the expression of TPP1 proteinPMID:34186270
Tpp1decreases expressionISOTPP1 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of TPP1 proteinPMID:37664457
Tpp1decreases methylationISOTPP1 (Homo sapiens)6480464CTDbisphenol A results in decreased methylation of TPP1 genePMID:31601247
Tpp1increases expressionISOTPP1 (Homo sapiens)6480464CTDbisphenol A results in increased expression of TPP1 mRNA; bisphenol A results in increased expression of TPP1 proteinPMID:29275510 PMID:37567409
Tpp1increases expressionISOTpp1 (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of TPP1 mRNAPMID:25181051
Tpp1multiple interactionsISOTPP1 (Homo sapiens)6480464CTD[bisphenol A co-treated with Fulvestrant] results in decreased methylation of TPP1 genePMID:31601247
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