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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732685
Species: Mus musculus
RGD Object: Gene
Symbol: Acox1
Name: acyl-Coenzyme A oxidase 1, palmitoyl
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acox1decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of ACOX1 mRNAPMID:37105096
Acox1increases expressionEXP 6480464CTDbisphenol A results in increased expression of ACOX1 mRNAPMID:27502578
Acox1multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diethyl phthalate co-treated with di-n-octyl phthalate co-treated with diisodecyl phthalate co-treated with diisononyl phthalate] results in decreased expression of ACOX1 mRNA; [Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of ACOX1 mRNAPMID:28433925 PMID:35739755
Acox1affects expressionISOAcox1 (Rattus norvegicus)6480464CTDbisphenol A affects the expression of ACOX1 mRNA; bisphenol A affects the expression of ACOX1 proteinPMID:25181051 PMID:30903817 PMID:32145629
Acox1decreases expressionISOACOX1 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of ACOX1 proteinPMID:34186270
Acox1decreases expressionISOAcox1 (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of ACOX1 mRNAPMID:23399309 PMID:25748669 PMID:32145629 PMID:34947998
Acox1multiple interactionsISOAcox1 (Rattus norvegicus)6480464CTDwortmannin inhibits the reaction [bisphenol A results in decreased expression of ACOX1 mRNA]PMID:23399309
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