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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732611
Species: Homo sapiens
RGD Object: Gene
Symbol: NFKBIB
Name: NFKB inhibitor beta
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NFKBIBdecreases methylationEXP 6480464CTDbisphenol A results in decreased methylation of NFKBIB genePMID:31601247
NFKBIBincreases expressionEXP 6480464CTDbisphenol A results in increased expression of NFKBIB mRNAPMID:19371625
NFKBIBmultiple interactionsEXP 6480464CTD[bisphenol A binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NFKBIB protein modified form]; bisphenol A inhibits the reaction [ESR1 protein binds to NFKBIB protein]; NFKBIB protein affects the reaction [bisphenol A results in decreased expression of APOA1 mRNA]PMID:28751236 PMID:29389661 PMID:31842455
NFKBIBdecreases expressionISONfkbib (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of NFKBIB mRNAPMID:30816183 PMID:32528016
NFKBIBincreases expressionISONfkbib (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of NFKBIB mRNAPMID:25181051
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