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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732271
Species: Homo sapiens
RGD Object: Gene
Symbol: MAPK8
Name: mitogen-activated protein kinase 8
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MAPK8decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of MAPK8 mRNAPMID:29275510
MAPK8increases phosphorylationEXP 6480464CTDbisphenol A results in increased phosphorylation of MAPK8 proteinPMID:33039870 PMID:36232920
MAPK8multiple interactionsEXP 6480464CTD1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK8 protein]; selonsertib inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK8 protein]PMID:33039870
MAPK8affects expressionISOMapk8 (Rattus norvegicus)6480464CTDbisphenol A affects the expression of MAPK8 mRNAPMID:25181051
MAPK8decreases expressionISOMapk8 (Mus musculus)6480464CTDbisphenol A results in decreased expression of MAPK8 mRNAPMID:33221593
MAPK8increases phosphorylationISOMapk8 (Rattus norvegicus)6480464CTDbisphenol A results in increased phosphorylation of MAPK8 proteinPMID:20096755 PMID:30496632
MAPK8increases phosphorylationISOMapk8 (Mus musculus)6480464CTDbisphenol A results in increased phosphorylation of MAPK8 proteinPMID:32575098
MAPK8multiple interactionsISOMapk8 (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of and results in increased phosphorylation of MAPK8 proteinPMID:17322771
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