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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732092
Species: Mus musculus
RGD Object: Gene
Symbol: Fzd2
Name: frizzled class receptor 2
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fzd2increases expressionEXP 6480464CTDbisphenol A results in increased expression of FZD2 mRNAPMID:24465770 PMID:32156529
Fzd2multiple interactionsEXP 6480464CTD[potassium bromate co-treated with bisphenol A] affects the expression of FZD2 mRNA; [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of FZD2 mRNA]PMID:27082013
Fzd2affects expressionISOFzd2 (Rattus norvegicus)6480464CTDbisphenol A affects the expression of FZD2 mRNAPMID:25181051
Fzd2increases methylationISOFZD2 (Homo sapiens)6480464CTDbisphenol A results in increased methylation of FZD2 genePMID:31601247
Fzd2multiple interactionsISOFZD2 (Homo sapiens)6480464CTD[bisphenol A co-treated with Fulvestrant] results in increased methylation of FZD2 gene; [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FZD2 mRNAPMID:28628672 PMID:31601247
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