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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731821
Species: Mus musculus
RGD Object: Gene
Symbol: Cdh2
Name: cadherin 2
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdh2decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of CDH2 mRNAPMID:33221593
Cdh2decreases expressionISOCdh2 (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of CDH2 proteinPMID:15082077
Cdh2decreases expressionISOCDH2 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of CDH2 mRNAPMID:29275510
Cdh2increases expressionISOCdh2 (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of CDH2 mRNA; bisphenol A results in increased expression of CDH2 proteinPMID:19782717 PMID:25181051 PMID:28355696 PMID:29323181 PMID:30816183 PMID:32145629
Cdh2increases expressionISOCDH2 (Homo sapiens)6480464CTDbisphenol A results in increased expression of CDH2 mRNA; bisphenol A results in increased expression of CDH2 proteinPMID:24997338 PMID:26363213 PMID:28808208 PMID:28844962 PMID:30611077
Cdh2increases methylationISOCdh2 (Rattus norvegicus)6480464CTDbisphenol A results in increased methylation of CDH2 genePMID:28505145
Cdh2increases methylationISOCDH2 (Homo sapiens)6480464CTDbisphenol A results in increased methylation of CDH2 genePMID:31601247
Cdh2multiple interactionsISOCdh2 (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of and affects the localization of CDH2 proteinPMID:19497385
Cdh2multiple interactionsISOCDH2 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of CDH2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of CDH2 protein]; 3,3'-diindolylmethane inhibits the reaction [bisphenol A results in increased expression of CDH2 protein]; [Phenolsulfonphthalein deficiency co-treated with bisphenol A] results in increased expression of CDH2 protein; bisphenol A results in decreased expression of and affects the localization of CDH2 protein; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of CDH2 protein]PMID:24532171 PMID:24997338 PMID:28808208 PMID:28844962 PMID:31629898
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