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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731593
Species: Homo sapiens
RGD Object: Gene
Symbol: PARD3
Name: par-3 family cell polarity regulator
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PARD3affects expressionEXP 6480464CTDbisphenol A affects the expression of PARD3 mRNAPMID:30903817
PARD3affects methylationEXP 6480464CTDbisphenol A affects the methylation of PARD3 genePMID:31601247
PARD3decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of PARD3 mRNAPMID:22576693
PARD3increases expressionEXP 6480464CTDbisphenol A results in increased expression of PARD3 mRNAPMID:29275510
PARD3increases methylationEXP 6480464CTDbisphenol A results in increased methylation of PARD3 genePMID:22576693
PARD3multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Fulvestrant] results in increased methylation of PARD3 gene; [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PARD3 mRNAPMID:28628672 PMID:31601247
PARD3affects expressionISOPard3 (Rattus norvegicus)6480464CTDbisphenol A affects the expression of PARD3 mRNAPMID:25181051
PARD3decreases methylationISOPard3 (Mus musculus)6480464CTDbisphenol A results in decreased methylation of PARD3 promoterPMID:27312807
PARD3increases expressionISOPard3 (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of PARD3 mRNAPMID:32145629
PARD3increases methylationISOPard3 (Rattus norvegicus)6480464CTDbisphenol A results in increased methylation of PARD3 genePMID:28505145
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