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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731530
Species: Mus musculus
RGD Object: Gene
Symbol: Gper1
Name: G protein-coupled estrogen receptor 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gper1decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of GPER1 mRNA; bisphenol A results in decreased expression of GPER1 proteinPMID:30149043 PMID:36347119
Gper1decreases methylationEXP 6480464CTDbisphenol A results in decreased methylation of GPER1 promoterPMID:27312807
Gper1increases activityEXP 6480464CTDbisphenol A results in increased activity of GPER1 proteinPMID:24604882
Gper1increases expressionEXP 6480464CTDbisphenol A results in increased expression of GPER1 mRNA; bisphenol A results in increased expression of GPER1 proteinPMID:22707478 PMID:23274518 PMID:24495410 PMID:28774890
Gper1multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A promotes the reaction [FOS protein binds to GPER1 promoter]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of GPER1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of GPER1 protein]; [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diethyl phthalate co-treated with di-n-octyl phthalate co-treated with diisodecyl phthalate co-treated with diisononyl phthalate] results in increased expression of GPER1 protein; [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in increased expression of GPER1 mRNA; [Dietary Sucrose co-treated with Dietary Fats co-treated with bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] affects the expression of GPER1 mRNA; AG 1879 inhibits the reaction [bisphenol A promotes the reaction [FOS protein binds to GPER1 promoter]]; AG 1879 inhibits the reaction [bisphenol A results in increased expression of GPER1 mRNA]; AG 1879 inhibits the reaction [bisphenol A results in increased expression of GPER1 protein]; bisphenol A promotes the reaction [FOS protein binds to GPER1 promoter]; FOS protein affects the reaction [bisphenol A results in increased expression of GPER1 mRNA]; FOS protein affects the reaction [bisphenol A results in increased expression of GPER1 protein]; GPER1 affects the reaction [bisphenol A results in increased expression of FOS mRNA]; GPER1 protein affects the reaction [[Fulvestrant co-treated with bisphenol A] results in decreased expression of CCND1 mRNA]; GPER1 protein affects the reaction [[Fulvestrant co-treated with bisphenol A] results in increased expression of FOS mRNA]; GPER1 protein affects the reaction [bisphenol A results in decreased expression of MIR338 mRNA]; GPER1 protein affects the reaction [bisphenol A results in increased expression of PDX1 mRNA]; GPER1 protein affects the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; GPER1 protein affects the reaction [bisphenol A results in increased phosphorylation of MAPK3 protein]; KT 5823 inhibits the reaction [bisphenol A promotes the reaction [FOS protein binds to GPER1 promoter]]; KT 5823 inhibits the reaction [bisphenol A results in increased expression of GPER1 mRNA]; KT 5823 inhibits the reaction [bisphenol A results in increased expression of GPER1 protein]; Pertussis Toxin inhibits the reaction [bisphenol A promotes the reaction [FOS protein binds to GPER1 promoter]]; Pertussis Toxin inhibits the reaction [bisphenol A results in increased expression of GPER1 mRNA]; Pertussis Toxin inhibits the reaction [bisphenol A results in increased expression of GPER1 protein]; RTKI cpd inhibits the reaction [bisphenol A promotes the reaction [FOS protein binds to GPER1 promoter]]; RTKI cpd inhibits the reaction [bisphenol A results in increased expression of GPER1 mRNA]; RTKI cpd inhibits the reaction [bisphenol A results in increased expression of GPER1 protein]PMID:21813366 PMID:23274518 PMID:28446726 PMID:28774890 PMID:30722647 PMID:35739755 PMID:37364641
Gper1affects bindingISOGPER1 (Homo sapiens)6480464CTDbisphenol A binds to GPER1 proteinPMID:28858478 PMID:34328988
Gper1decreases expressionISOGper1 (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of GPER1 mRNAPMID:25181051 PMID:30755151
Gper1decreases expressionISOGPER1 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of GPER1 mRNA; bisphenol A results in decreased expression of GPER1 proteinPMID:25878060 PMID:32030086 PMID:32963737 PMID:34602561 PMID:34831106 PMID:36235125
Gper1increases expressionISOGper1 (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of GPER1 mRNAPMID:24189132
Gper1increases expressionISOGPER1 (Homo sapiens)6480464CTDbisphenol A results in increased expression of GPER mRNA; bisphenol A results in increased expression of GPER protein; bisphenol A results in increased expression of GPER1 mRNA; bisphenol A results in increased expression of GPER1 proteinPMID:28426875 PMID:28882636 PMID:29783106 PMID:31016847 PMID:32325111
Gper1multiple interactionsISOGper1 (Rattus norvegicus)6480464CTD[Estradiol co-treated with bisphenol A] results in decreased expression of GPER mRNAPMID:35700937
Gper1multiple interactionsISOGPER1 (Homo sapiens)6480464CTD[Estradiol co-treated with bisphenol A] results in increased expression of GPER1 mRNA; [Fulvestrant co-treated with 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline] inhibits the reaction [bisphenol A results in increased expression of GPER1 mRNA]; [GPER1 protein co-treated with bisphenol A] results in increased phosphorylation of MAPK1 protein; [GPER1 protein co-treated with bisphenol A] results in increased phosphorylation of MAPK3 protein; [GPER1 protein results in increased susceptibility to bisphenol A] which results in increased phosphorylation of MAPK1 protein; [GPER1 protein results in increased susceptibility to bisphenol A] which results in increased phosphorylation of MAPK3 protein; bisphenol A binds to and results in increased activity of GPER1 protein; daidzein inhibits the reaction [bisphenol A results in decreased expression of GPER1 mRNA]; Genistein inhibits the reaction [bisphenol A results in decreased expression of GPER1 mRNA]; GPER1 mRNA affects the reaction [bisphenol A results in increased expression of CCN2 protein]; GPER1 mRNA affects the reaction [bisphenol A results in increased expression of EGR1 protein]; GPER1 mRNA affects the reaction [bisphenol A results in increased expression of FOS protein]; GPER1 mRNA affects the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; GPER1 mRNA affects the reaction [bisphenol A results in increased phosphorylation of MAPK3 protein]; GPER1 protein affects the reaction [bisphenol A results in increased expression of IL6 mRNA]; GPER1 protein affects the reaction [bisphenol A results in increased expression of WDR5 protein]; GPER1 protein affects the reaction [bisphenol A results in increased phosphorylation of PTK2 protein]; GPER1 protein affects the reaction [bisphenol A results in increased phosphorylation of SRC protein]; GPER1 protein affects the reaction [bisphenol A results in increased phosphorylation of STAT3 protein]; GPER1 protein promotes the reaction [bisphenol A results in increased expression of FOS mRNA]; GPER1 protein promotes the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]PMID:17088055 PMID:20875696 PMID:22552965 PMID:28466560 PMID:28882636 PMID:29783106 PMID:32325111 PMID:32963737 PMID:33022573 PMID:37372083
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