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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731284
Species: Homo sapiens
RGD Object: Gene
Symbol: HSD17B4
Name: hydroxysteroid 17-beta dehydrogenase 4
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HSD17B4decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of HSD17B4 proteinPMID:34186270 PMID:37567409
HSD17B4decreases expressionISOHsd17b4 (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of HSD17B4 mRNAPMID:30816183 PMID:32528016 PMID:34947998
HSD17B4decreases expressionISOHsd17b4 (Mus musculus)6480464CTDbisphenol A results in decreased expression of HSD17B4 mRNAPMID:33221593
HSD17B4increases expressionISOHsd17b4 (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of HSD17B4 mRNAPMID:25181051
HSD17B4multiple interactionsISOHsd17b4 (Rattus norvegicus)6480464CTD[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of HSD17B4 mRNA; [bisphenol A co-treated with Estradiol] results in decreased expression of HSD17B4 mRNAPMID:26496021 PMID:36041667
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