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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730821
Species: Homo sapiens
RGD Object: Gene
Symbol: MMP2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MMP2decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of MMP2 mRNA; bisphenol A results in decreased expression of MMP2 proteinPMID:31230753 PMID:31675489 PMID:32981897 PMID:34186270
MMP2decreases methylationEXP 6480464CTDbisphenol A results in decreased methylation of MMP2 genePMID:31601247
MMP2increases expressionEXP 6480464CTDbisphenol A results in increased expression of MMP2 mRNA; bisphenol A results in increased expression of MMP2 proteinPMID:19956873 PMID:24997338 PMID:25312822 PMID:26407941 PMID:27038254 PMID:27685785 PMID:28466560 PMID:28844962 PMID:29275510 PMID:33683587
MMP2multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of and results in increased activity of MMP2 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of MMP2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of and results in increased activity of MMP2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of MMP2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of MMP2 protein]; 3,3'-diindolylmethane inhibits the reaction [bisphenol A results in increased expression of MMP2 protein]; 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [bisphenol A results in increased expression of MMP2 protein]; [bisphenol A co-treated with Fulvestrant] results in decreased methylation of MMP2 gene; bisphenol A results in increased expression of and results in increased activity of MMP2 protein; ESRRG protein affects the reaction [bisphenol A results in increased expression of MMP2 mRNA]; ESRRG protein affects the reaction [bisphenol A results in increased expression of MMP2 protein]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of MMP2 mRNA]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of MMP2 protein]; Genistein inhibits the reaction [bisphenol A results in increased expression of MMP2 protein]; RTKI cpd inhibits the reaction [bisphenol A results in increased expression of MMP2 protein]PMID:19956873 PMID:24997338 PMID:25312822 PMID:26407941 PMID:27038254 PMID:28844962 PMID:31601247
MMP2affects expressionISOMmp2 (Rattus norvegicus)6480464CTDbisphenol A affects the expression of MMP2 mRNAPMID:25181051
MMP2decreases expressionISOMmp2 (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of MMP2 mRNAPMID:34947998
MMP2decreases expressionISOMmp2 (Mus musculus)6480464CTDbisphenol A results in decreased expression of MMP2 mRNA; bisphenol A results in decreased expression of MMP2 proteinPMID:30303745 PMID:33930482
MMP2increases expressionISOMmp2 (Mus musculus)6480464CTDbisphenol A results in increased expression of MMP2 mRNA; bisphenol A results in increased expression of MMP2 proteinPMID:28903498 PMID:30951980 PMID:35479511
MMP2increases methylationISOMmp2 (Rattus norvegicus)6480464CTDbisphenol A results in increased methylation of MMP2 genePMID:28505145
MMP2multiple interactionsISOMmp2 (Mus musculus)6480464CTD[bisphenol A co-treated with Tretinoin] results in decreased expression of MMP2 mRNA; bisphenol A results in increased expression of and results in increased activity of MMP2 protein; CREB3 protein affects the reaction [bisphenol A results in decreased expression of MMP2 mRNA]; CREB3 protein affects the reaction [bisphenol A results in decreased expression of MMP2 protein]PMID:25862758 PMID:30951980 PMID:33930482
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