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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70973
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cacna1d
Name: calcium voltage-gated channel subunit alpha1 D
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cacna1ddecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of CACNA1D mRNAPMID:25181051 PMID:30816183 PMID:32528016
Cacna1dincreases methylationEXP 6480464CTDbisphenol A results in increased methylation of CACNA1D genePMID:28505145
Cacna1dmultiple interactionsEXP 6480464CTD[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of CACNA1D mRNA; [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of CACNA1D mRNA; [bisphenol A co-treated with Estradiol] results in decreased expression of CACNA1D mRNA; [bisphenol A co-treated with Testosterone] results in increased expression of CACNA1D mRNAPMID:25607892 PMID:26496021
Cacna1ddecreases expressionISOCacna1d (Mus musculus)6480464CTDbisphenol A results in decreased expression of CACNA1D mRNAPMID:32156529 PMID:38074096
Cacna1dincreases expressionISOCacna1d (Mus musculus)6480464CTDbisphenol A results in increased expression of CACNA1D mRNAPMID:30245210 PMID:35598803
Cacna1dmultiple interactionsISOCACNA1D (Homo sapiens)6480464CTD[bisphenol A co-treated with Fulvestrant] results in increased methylation of CACNA1D genePMID:31601247
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