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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70935
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mbtps1
Name: membrane-bound transcription factor peptidase, site 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mbtps1decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of MBTPS1 mRNAPMID:25181051
Mbtps1multiple interactionsEXP 6480464CTD[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of MBTPS1 mRNAPMID:36041667
Mbtps1decreases expressionISOMBTPS1 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of MBTPS1 mRNA; bisphenol A results in decreased expression of MBTPS1 proteinPMID:25047013 PMID:31675489
Mbtps1decreases methylationISOMBTPS1 (Homo sapiens)6480464CTDbisphenol A results in decreased methylation of MBTPS1 promoterPMID:30352284
Mbtps1decreases methylationISOMbtps1 (Mus musculus)6480464CTDbisphenol A results in decreased methylation of MBTPS1 promoterPMID:27312807
Mbtps1increases expressionISOMBTPS1 (Homo sapiens)6480464CTDbisphenol A results in increased expression of MBTPS1 mRNAPMID:29275510
Mbtps1multiple interactionsISOMBTPS1 (Homo sapiens)6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of MBTPS1 mRNAPMID:28628672
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