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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70927
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mgst1
Name: microsomal glutathione S-transferase 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mgst1affects expressionEXP 6480464CTDbisphenol A affects the expression of MGST1 mRNAPMID:30903817
Mgst1decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of MGST1 mRNAPMID:12075121
Mgst1increases expressionEXP 6480464CTDbisphenol A results in increased expression of MGST1 mRNAPMID:25181051 PMID:33296240
Mgst1increases methylationEXP 6480464CTDbisphenol A results in increased methylation of MGST1 genePMID:28505145
Mgst1affects expressionISOMGST1 (Homo sapiens)6480464CTDbisphenol A affects the expression of MGST1 mRNAPMID:30903817
Mgst1decreases expressionISOMGST1 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of MGST1 mRNA; bisphenol A results in decreased expression of MGST1 proteinPMID:22576693 PMID:37567409
Mgst1increases expressionISOMgst1 (Mus musculus)6480464CTDbisphenol A results in increased expression of MGST1 mRNAPMID:28123100 PMID:33221593
Mgst1increases expressionISOMGST1 (Homo sapiens)6480464CTDbisphenol A results in increased expression of MGST1 proteinPMID:34186270
Mgst1increases methylationISOMGST1 (Homo sapiens)6480464CTDbisphenol A results in increased methylation of MGST1 genePMID:22576693
Mgst1multiple interactionsISOMgst1 (Mus musculus)6480464CTD[LRAT gene mutant form affects the susceptibility to [bisphenol A co-treated with retinol acetate]] which results in increased expression of MGST1 mRNAPMID:28123100
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