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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68945
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp4a1
Name: cytochrome P450, family 4, subfamily a, polypeptide 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp4a1affects expressionEXP 6480464CTDbisphenol A affects the expression of CYP4A1 mRNA; bisphenol A affects the expression of CYP4A22 mRNAPMID:25181051 PMID:30903817
Cyp4a1decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of CYP4A1 mRNAPMID:32145629
Cyp4a1decreases methylationISOCYP4A22 (Homo sapiens)6480464CTDbisphenol A results in decreased methylation of CYP4A22 genePMID:31601247
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