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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68468
Species: Homo sapiens
RGD Object: Gene
Symbol: POR
Name: cytochrome p450 oxidoreductase
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PORaffects expressionEXP 6480464CTDbisphenol A affects the expression of POR mRNAPMID:30903817
PORdecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of POR proteinPMID:37567409
PORdecreases methylationEXP 6480464CTDbisphenol A results in decreased methylation of POR genePMID:31601247
PORincreases expressionEXP 6480464CTDbisphenol A results in increased expression of POR mRNA; bisphenol A results in increased expression of POR proteinPMID:29275510 PMID:33258555 PMID:34186270
PORmultiple interactionsEXP 6480464CTDbisphenol A promotes the reaction [POR protein binds to ESR1 protein]PMID:27156127
PORaffects expressionISOPor (Rattus norvegicus)6480464CTDbisphenol A affects the expression of POR mRNAPMID:30903817
PORdecreases expressionISOPor (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of POR mRNA; bisphenol A results in decreased expression of POR proteinPMID:24752506 PMID:30816183 PMID:32145629 PMID:32528016 PMID:33296240 PMID:34947998
PORincreases expressionISOPor (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of POR mRNAPMID:25181051
PORincreases expressionISOPor (Mus musculus)6480464CTDbisphenol A results in increased expression of POR mRNAPMID:32156529
PORmultiple interactionsISOPor (Rattus norvegicus)6480464CTD[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of POR mRNAPMID:36041667
PORmultiple interactionsISOPor (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of POR mRNAPMID:28433925
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