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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68411
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sh2b3
Name: SH2B adaptor protein 3
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sh2b3increases expressionEXP 6480464CTDbisphenol A results in increased expression of SH2B3 mRNAPMID:25181051
Sh2b3decreases methylationISOSh2b3 (Mus musculus)6480464CTDbisphenol A results in decreased methylation of SH2B3 promoterPMID:27312807
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