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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62396
Species: Mus musculus
RGD Object: Gene
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDbisphenol A results in increased expression of DDIT3 mRNA, bisphenol A results in increased expression of DDIT3 protein

PMID:12233820, PMID:12732195, PMID:16713995, PMID:20807545, PMID:28641223, PMID:28910977, PMID:29935216
increases response to substanceEXP 6480464CTDDDIT3 protein results in increased susceptibility to bisphenol A

PMID:12732195
multiple interactionsEXP 6480464CTD[Streptozocin co-treated with bisphenol A] results in increased expression of DDIT3 protein, Streptozocin promotes the reaction [bisphenol A results in increased expression of DDIT3 mRNA]

PMID:29935216
affects expressionISORGD:691656480464CTDbisphenol A affects the expression of DDIT3 mRNA

PMID:20170705, PMID:30903817
decreases expressionISORGD:623916480464CTDbisphenol A results in decreased expression of DDIT3 mRNA

PMID:26982218
decreases methylationISORGD:691656480464CTDbisphenol A results in decreased methylation of DDIT3 promoter

PMID:30352284
increases expressionISORGD:623916480464CTDbisphenol A results in increased expression of DDIT3 mRNA

PMID:25181051, PMID:25461909
increases expressionISORGD:691656480464CTDbisphenol A results in increased expression of DDIT3 mRNA

PMID:25619500, PMID:29275510
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.