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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62335
Species: Mus musculus
RGD Object: Gene
Symbol: Xdh
Name: xanthine dehydrogenase
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Xdhincreases activityEXP 6480464CTDbisphenol A results in increased activity of XDH proteinPMID:31574244
Xdhincreases expressionEXP 6480464CTDbisphenol A results in increased expression of XDH mRNAPMID:26063408 PMID:32156529
Xdhmultiple interactionsEXP 6480464CTD[bisphenol A results in increased activity of XDH protein] which results in increased chemical synthesis of Uric AcidPMID:31574244
Xdhdecreases expressionISOXdh (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of XDH mRNA; bisphenol A results in decreased expression of XDH proteinPMID:24552547 PMID:25181051 PMID:32145629
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