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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621869
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rapgef3
Name: Rap guanine nucleotide exchange factor 3
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDbisphenol A affects the expression of RAPGEF3 mRNA

PMID:25181051
increases methylationEXP 6480464CTDbisphenol A results in increased methylation of RAPGEF3 gene

PMID:28505145
affects expressionISORGD:13512166480464CTDbisphenol A affects the expression of RAPGEF3 mRNA

PMID:20170705, PMID:22574217
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.