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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621543
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chek2
Name: checkpoint kinase 2
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chek2decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of CHEK2 mRNAPMID:25181051 PMID:34947998
Chek2increases phosphorylationEXP 6480464CTDbisphenol A results in increased phosphorylation of CHEK2 proteinPMID:23788033 PMID:25344109
Chek2multiple interactionsEXP 6480464CTD[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of CHEK2 mRNA; Fulvestrant inhibits the reaction [bisphenol A results in increased phosphorylation of CHEK2 protein]PMID:23788033 PMID:36041667
Chek2decreases expressionISOCHEK2 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of CHEK2 mRNAPMID:36982678
Chek2decreases methylationISOCHEK2 (Homo sapiens)6480464CTDbisphenol A results in decreased methylation of CHEK2 genePMID:31601247
Chek2increases phosphorylationISOCHEK2 (Homo sapiens)6480464CTDbisphenol A results in increased phosphorylation of CHEK2 proteinPMID:32466334 PMID:36232920
Chek2multiple interactionsISOCHEK2 (Homo sapiens)6480464CTD[naringenin co-treated with bisphenol A] results in increased expression of CHEK2 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CHEK2 mRNAPMID:36235125
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