GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Chek2 | decreases expression | EXP | | 6480464 | CTD | bisphenol A results in decreased expression of CHEK2 mRNA | PMID:25181051 PMID:34947998 | Chek2 | increases phosphorylation | EXP | | 6480464 | CTD | bisphenol A results in increased phosphorylation of CHEK2 protein | PMID:23788033 PMID:25344109 | Chek2 | multiple interactions | EXP | | 6480464 | CTD | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of CHEK2 mRNA; Fulvestrant inhibits the reaction [bisphenol A results in increased phosphorylation of CHEK2 protein] | PMID:23788033 PMID:36041667 | Chek2 | decreases expression | ISO | CHEK2 (Homo sapiens) | 6480464 | CTD | bisphenol A results in decreased expression of CHEK2 mRNA | PMID:36982678 | Chek2 | decreases methylation | ISO | CHEK2 (Homo sapiens) | 6480464 | CTD | bisphenol A results in decreased methylation of CHEK2 gene | PMID:31601247 | Chek2 | increases phosphorylation | ISO | CHEK2 (Homo sapiens) | 6480464 | CTD | bisphenol A results in increased phosphorylation of CHEK2 protein | PMID:32466334 PMID:36232920 | Chek2 | multiple interactions | ISO | CHEK2 (Homo sapiens) | 6480464 | CTD | [naringenin co-treated with bisphenol A] results in increased expression of CHEK2 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CHEK2 mRNA | PMID:36235125 | |
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