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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621503
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcnq1
Name: potassium voltage-gated channel subfamily Q member 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnq1decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of KCNQ1 mRNAPMID:25181051
Kcnq1increases methylationEXP 6480464CTDbisphenol A results in increased methylation of KCNQ1 genePMID:28505145
Kcnq1multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Estradiol] results in increased expression of KCNQ1 mRNAPMID:26496021
Kcnq1decreases methylationISOKCNQ1 (Homo sapiens)6480464CTDbisphenol A results in decreased methylation of KCNQ1 genePMID:31601247
Kcnq1decreases methylationISOKcnq1 (Mus musculus)6480464CTDbisphenol A results in decreased methylation of KCNQ1 promoterPMID:27312807
Kcnq1increases expressionISOKcnq1 (Mus musculus)6480464CTDbisphenol A results in increased expression of KCNQ1 mRNAPMID:31649729
Kcnq1increases methylationISOKcnq1 (Mus musculus)6480464CTDbisphenol A results in increased methylation of KCNQ1 promoterPMID:27312807
Kcnq1multiple interactionsISOKCNQ1 (Homo sapiens)6480464CTD[bisphenol A co-treated with Fulvestrant] results in decreased methylation of KCNQ1 genePMID:31601247
Kcnq1multiple interactionsISOKcnq1 (Mus musculus)6480464CTD[bisphenol A results in decreased methylation of KCNQ1 intron] which results in decreased abundance of 5-hydroxymethylcytosinePMID:30044229
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