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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621399
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Skil
Name: SKI-like proto-oncogene
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDbisphenol A affects the expression of SKIL mRNA

PMID:25181051
increases expressionEXP 6480464CTDbisphenol A results in increased expression of SKIL mRNA

PMID:29097150
increases expressionISORGD:13148306480464CTDbisphenol A results in increased expression of SKIL protein

PMID:24308608, PMID:26407941
multiple interactionsISORGD:13148306480464CTDfulvestrant inhibits the reaction [bisphenol A results in increased expression of SKIL protein], Genistein inhibits the reaction [bisphenol A results in increased expression of SKIL protein]

PMID:26407941
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.