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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621246
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Top1
Name: DNA topoisomerase I
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Top1decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of TOP1 mRNAPMID:25181051
Top1multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Testosterone] results in decreased expression of TOP1 mRNAPMID:26496021
Top1affects expressionISOTOP1 (Homo sapiens)6480464CTDbisphenol A affects the expression of TOP1 mRNA; bisphenol A affects the expression of TOP1 proteinPMID:30903817 PMID:37567409
Top1decreases expressionISOTOP1 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of TOP1 proteinPMID:31675489
Top1increases expressionISOTop1 (Mus musculus)6480464CTDbisphenol A results in increased expression of TOP1 mRNAPMID:26063408
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