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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620471
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sox5
Name: SRY-box transcription factor 5
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sox5decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of SOX5 mRNAPMID:25181051 PMID:30816183 PMID:36803626
Sox5increases methylationEXP 6480464CTDbisphenol A results in increased methylation of SOX5 genePMID:28505145
Sox5multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Genistein] results in increased methylation of SOX5 genePMID:28505145
Sox5affects expressionISOSOX5 (Homo sapiens)6480464CTDbisphenol A affects the expression of SOX5 mRNAPMID:20170705
Sox5affects methylationISOSOX5 (Homo sapiens)6480464CTDbisphenol A affects the methylation of SOX5 genePMID:31601247
Sox5increases methylationISOSOX5 (Homo sapiens)6480464CTDbisphenol A results in increased methylation of SOX5 promoterPMID:27271280
Sox5multiple interactionsISOSOX5 (Homo sapiens)6480464CTD[bisphenol A co-treated with Fulvestrant] affects the methylation of SOX5 genePMID:31601247
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