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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620435
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sos2
Name: SOS Ras/Rho guanine nucleotide exchange factor 2
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sos2increases expressionEXP 6480464CTDbisphenol A results in increased expression of SOS2 mRNAPMID:25181051 PMID:33296240 PMID:34947998
Sos2decreases expressionISOSos2 (Mus musculus)6480464CTDbisphenol A results in decreased expression of SOS2 mRNAPMID:33221593
Sos2increases methylationISOSOS2 (Homo sapiens)6480464CTDbisphenol A results in increased methylation of SOS2 genePMID:31601247
Sos2multiple interactionsISOSOS2 (Homo sapiens)6480464CTD[bisphenol A co-treated with Fulvestrant] results in increased methylation of SOS2 genePMID:31601247
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