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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619774
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Wif1
Name: Wnt inhibitory factor 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Wif1decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of WIF1 mRNAPMID:25181051 PMID:30816183 PMID:32528016
Wif1increases expressionEXP 6480464CTDbisphenol A results in increased expression of WIF1 mRNA; bisphenol A results in increased expression of WIF1 proteinPMID:25381574 PMID:25963729
Wif1increases methylationEXP 6480464CTDbisphenol A results in increased methylation of WIF1 genePMID:28505145
Wif1multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Estradiol] results in decreased expression of WIF1 mRNA; Curcumin inhibits the reaction [bisphenol A results in increased expression of WIF1 protein]PMID:25963729 PMID:26496021
Wif1increases expressionISOWif1 (Mus musculus)6480464CTDbisphenol A results in increased expression of WIF1 mRNAPMID:30951980
Wif1multiple interactionsISOWif1 (Mus musculus)6480464CTD[bisphenol A results in increased susceptibility to Estradiol] which results in increased expression of WIF1 mRNAPMID:27312807
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