GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3911
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tshr
Name: thyroid stimulating hormone receptor
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of TSHR mRNA

PMID:25181051
increases expressionEXP 6480464CTDbisphenol A results in increased expression of TSHR mRNA

PMID:23238275
multiple interactionsISORGD:7370216480464CTDbisphenol A inhibits the reaction [[TSHB protein results in increased activity of TSHR protein] which results in increased abundance of Cyclic AMP]

PMID:19766106
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.