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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3715
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc6a3
Name: solute carrier family 6 member 3
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc6a3affects localizationEXP 6480464CTDbisphenol A affects the localization of SLC6A3 proteinPMID:19479021
Slc6a3decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of SLC6A3 mRNAPMID:15079872 PMID:17689037 PMID:25181051
Slc6a3multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Estradiol] inhibits the reaction [SLC6A3 protein affects the export of Dopamine]; bisphenol A affects the reaction [SLC6A3 protein affects the export of Dopamine]PMID:19479021
Slc6a3decreases methylationISOSLC6A3 (Homo sapiens)6480464CTDbisphenol A results in decreased methylation of SLC6A3 genePMID:31601247
Slc6a3increases expressionISOSlc6a3 (Mus musculus)6480464CTDbisphenol A results in increased expression of SLC6A3 mRNAPMID:30951980
Slc6a3increases expressionISOSLC6A3 (Homo sapiens)6480464CTDbisphenol A results in increased expression of SLC6A3 proteinPMID:27494678
Slc6a3multiple interactionsISOSLC6A3 (Homo sapiens)6480464CTD[bisphenol A co-treated with Fulvestrant] results in decreased methylation of SLC6A3 genePMID:31601247
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