Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3534
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rara
Name: retinoic acid receptor, alpha
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Raradecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of RARA mRNAPMID:33296240
Raraincreases expressionEXP 6480464CTDbisphenol A results in increased expression of RARA mRNAPMID:25181051 PMID:32145629
Raraaffects methylationISORara (Mus musculus)6480464CTDbisphenol A affects the methylation of RARA promoterPMID:27334623
Raradecreases expressionISORara (Mus musculus)6480464CTDbisphenol A results in decreased expression of RARA mRNAPMID:14967906
Raraincreases expressionISORara (Mus musculus)6480464CTDbisphenol A results in increased expression of RARA mRNAPMID:14967906 PMID:15738621 PMID:32156529
Raramultiple interactionsISORARA (Homo sapiens)6480464CTD[bisphenol A co-treated with Fulvestrant] results in increased methylation of RARA gene; [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of RARA mRNA; bisphenol A inhibits the reaction [ESR1 protein binds to RARA promoter]PMID:28628672 PMID:31601247 PMID:36572933
Go Back to source page   Continue to Ontology report