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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3310
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pfkfb4
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pfkfb4decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of PFKFB4 mRNAPMID:25181051
Pfkfb4increases expressionEXP 6480464CTDbisphenol A results in increased expression of PFKFB4 mRNAPMID:17010207
Pfkfb4increases methylationEXP 6480464CTDbisphenol A results in increased methylation of PFKFB4 genePMID:28505145
Pfkfb4multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Estradiol] results in decreased expression of PFKFB4 mRNAPMID:26496021
Pfkfb4affects expressionISOPFKFB4 (Homo sapiens)6480464CTDbisphenol A affects the expression of PFKFB4 mRNAPMID:30903817
Pfkfb4increases expressionISOPfkfb4 (Mus musculus)6480464CTDbisphenol A results in increased expression of PFKFB4 mRNAPMID:34585602
Pfkfb4increases methylationISOPfkfb4 (Mus musculus)6480464CTDbisphenol A results in increased methylation of PFKFB4 promoterPMID:27312807
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