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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3173
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfyc
Name: nuclear transcription factor Y subunit gamma
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of NFYC mRNA

PMID:25181051
increases methylationEXP 6480464CTDbisphenol A results in increased methylation of NFYC gene

PMID:28505145
affects methylationISORGD:109776480464CTDbisphenol A affects the methylation of NFYC promoter

PMID:27334623
increases expressionISORGD:7318436480464CTDbisphenol A results in increased expression of NFYC mRNA

PMID:15223131
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.