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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2845
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Htr1a
Name: 5-hydroxytryptamine receptor 1A
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Htr1adecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of HTR1A mRNAPMID:25181051 PMID:26186136
Htr1adecreases expressionISOHtr1a (Mus musculus)6480464CTDbisphenol A results in decreased expression of HTR1A mRNAPMID:32365465
Htr1adecreases methylationISOHtr1a (Mus musculus)6480464CTDbisphenol A results in decreased methylation of HTR1A promoterPMID:27312807
Htr1adecreases methylationISOHTR1A (Homo sapiens)6480464CTDbisphenol A results in decreased methylation of HTR1A promoterPMID:27271280
Htr1aincreases methylationISOHtr1a (Mus musculus)6480464CTDbisphenol A results in increased methylation of HTR1A promoterPMID:27312807
Htr1amultiple interactionsISOHtr1a (Mus musculus)6480464CTD[diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3,5,6-trichloro-2-pyridinol co-treated with 3-phenoxybenzoic acid co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of HTR1A mRNAPMID:32518293
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