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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2781
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Has2
Name: hyaluronan synthase 2
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Has2decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of HAS2 mRNAPMID:25181051 PMID:30816183
Has2increases expressionEXP 6480464CTDbisphenol A results in increased expression of HAS2 mRNAPMID:34947998
Has2multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Estradiol] results in increased expression of HAS2 mRNA; [bisphenol A co-treated with Testosterone] results in increased expression of HAS2 mRNAPMID:26496021
Has2decreases expressionISOHAS2 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of HAS2 mRNAPMID:27685785 PMID:28951153 PMID:29275510
Has2decreases expressionISOHas2 (Mus musculus)6480464CTDbisphenol A results in decreased expression of HAS2 mRNAPMID:35479511
Has2increases expressionISOHas2 (Mus musculus)6480464CTDbisphenol A results in increased expression of HAS2 mRNAPMID:30951980
Has2multiple interactionsISOHAS2 (Homo sapiens)6480464CTD[bisphenol A co-treated with Fulvestrant] results in increased methylation of HAS2 genePMID:31601247
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