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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2737
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Grin2a
Name: glutamate ionotropic receptor NMDA type subunit 2A
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Grin2aaffects expressionEXP 6480464CTDbisphenol A affects the expression of GRIN2A mRNAPMID:34434659
Grin2adecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of GRIN2A mRNA; bisphenol A results in decreased expression of GRIN2A proteinPMID:20821433 PMID:30816183 PMID:32528016 PMID:32629208
Grin2aincreases methylationEXP 6480464CTDbisphenol A results in increased methylation of GRIN2A genePMID:28505145
Grin2amultiple interactionsEXP 6480464CTDastragaloside A inhibits the reaction [bisphenol A affects the expression of GRIN2A mRNA]; Saponins inhibits the reaction [bisphenol A affects the expression of GRIN2A mRNA]PMID:34434659
Grin2adecreases expressionISOGrin2a (Mus musculus)6480464CTDbisphenol A results in decreased expression of GRIN2A mRNA; bisphenol A results in decreased expression of GRIN2A proteinPMID:20206181 PMID:28572023 PMID:31064381 PMID:32156529
Grin2adecreases expressionISOGRIN2A (Homo sapiens)6480464CTDbisphenol A results in decreased expression of GRIN2A mRNAPMID:31715268
Grin2amultiple interactionsISOGrin2a (Mus musculus)6480464CTDAshwagandha inhibits the reaction [bisphenol A results in decreased expression of GRIN2A protein]; diphenyldiselenide inhibits the reaction [bisphenol A results in decreased expression of GRIN2A protein]PMID:28572023 PMID:31064381
Grin2amultiple interactionsISOGRIN2A (Homo sapiens)6480464CTD[bisphenol A co-treated with Fulvestrant] results in increased methylation of GRIN2A genePMID:31601247
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