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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2654
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gadd45a
Name: growth arrest and DNA-damage-inducible, alpha
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gadd45adecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of GADD45A mRNAPMID:30816183 PMID:34947998
Gadd45aincreases expressionEXP 6480464CTDbisphenol A results in increased expression of GADD45A mRNAPMID:12075121 PMID:25181051 PMID:32145629
Gadd45aaffects expressionISOGADD45A (Homo sapiens)6480464CTDbisphenol A affects the expression of GADD45A mRNAPMID:30903817
Gadd45adecreases expressionISOGADD45A (Homo sapiens)6480464CTDbisphenol A results in decreased expression of GADD45A mRNA; bisphenol A results in decreased expression of GADD45A proteinPMID:16474171 PMID:20678512 PMID:21277958 PMID:33312107
Gadd45amultiple interactionsISOGADD45A (Homo sapiens)6480464CTD[bisphenol A co-treated with cylindrospermopsin] results in increased expression of GADD45A mRNA; [bisphenol A co-treated with Quercetin] results in decreased expression of GADD45A mRNA; [naringenin co-treated with bisphenol A] results in increased expression of GADD45A mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of GADD45A mRNAPMID:32244372 PMID:36235125 PMID:36982678
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