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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2268
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Capn2
Name: calpain 2
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Capn2decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of CAPN2 mRNAPMID:30816183 PMID:32528016 PMID:34947998
Capn2increases expressionEXP 6480464CTDbisphenol A results in increased expression of CAPN2 mRNAPMID:25181051
Capn2increases methylationEXP 6480464CTDbisphenol A results in increased methylation of CAPN2 genePMID:28505145
Capn2affects expressionISOCAPN2 (Homo sapiens)6480464CTDbisphenol A affects the expression of CAPN2 mRNAPMID:30903817
Capn2decreases expressionISOCAPN2 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of CAPN2 proteinPMID:31675489
Capn2decreases methylationISOCAPN2 (Homo sapiens)6480464CTDbisphenol A results in decreased methylation of CAPN2 genePMID:31601247
Capn2increases expressionISOCAPN2 (Homo sapiens)6480464CTDbisphenol A analog results in increased expression of CAPN2 mRNA; bisphenol A results in increased expression of CAPN2 proteinPMID:32387340 PMID:37567409
Capn2increases expressionISOCapn2 (Mus musculus)6480464CTDbisphenol A results in increased expression of CAPN2 mRNAPMID:34585602
Capn2multiple interactionsISOCAPN2 (Homo sapiens)6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CAPN2 mRNAPMID:28628672
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