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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2258
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Calm2
Name: calmodulin 2
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Calm2increases expressionEXP 6480464CTDbisphenol A results in increased expression of CALM2 mRNAPMID:32145629
Calm2increases methylationEXP 6480464CTDbisphenol A results in increased methylation of CALM2 genePMID:28505145
Calm2multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Estradiol] results in increased expression of CALM2 mRNAPMID:26496021
Calm2affects expressionISOCALM2 (Homo sapiens)6480464CTDbisphenol A affects the expression of CALM2 mRNAPMID:30903817
Calm2decreases expressionISOCalm2 (Mus musculus)6480464CTDbisphenol A results in decreased expression of CALM2 mRNA; bisphenol A results in decreased expression of CALM2 proteinPMID:31566189 PMID:33221593 PMID:35999755
Calm2decreases expressionISOCALM2 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of CALM2 proteinPMID:34186270
Calm2multiple interactionsISOCalm2 (Mus musculus)6480464CTD[Dextran Sulfate co-treated with bisphenol A] results in decreased expression of CALM2 protein; Mifepristone inhibits the reaction [bisphenol A results in decreased expression of CALM2 mRNA]PMID:31566189 PMID:35999755
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