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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2232
Species: Rattus norvegicus
RGD Object: Gene
Symbol: C3
Name: complement C3
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
C3affects expressionEXP 6480464CTDbisphenol A affects the expression of C3 mRNA; bisphenol A affects the expression of C3 proteinPMID:25181051 PMID:30903817 PMID:32145629
C3decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of C3 mRNA; bisphenol A results in decreased expression of C3 proteinPMID:26788107
C3increases expressionEXP 6480464CTDbisphenol A results in increased expression of C3 mRNA; bisphenol A results in increased expression of C3 proteinPMID:10822019 PMID:11086226 PMID:15456929
C3affects expressionISOC3 (Homo sapiens)6480464CTDbisphenol A affects the expression of C3 mRNAPMID:30903817
C3decreases expressionISOC3 (Mus musculus)6480464CTDbisphenol A results in decreased expression of C3 mRNAPMID:33221593
C3increases expressionISOC3 (Mus musculus)6480464CTDbisphenol A results in increased expression of C3 mRNAPMID:23798566 PMID:30245210 PMID:32156529 PMID:34585602
C3multiple interactionsISOC3 (Mus musculus)6480464CTD[Dextran Sulfate co-treated with bisphenol A] results in increased expression of C3 proteinPMID:35999755
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