GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Bax | increases expression | EXP | | 6480464 | CTD | bisphenol A results in increased expression of BAX; bisphenol A results in increased expression of BAX mRNA; bisphenol A results in increased expression of BAX protein | PMID:23146694 PMID:23328667 PMID:24768697 PMID:25181051 PMID:25381574 PMID:25461564 PMID:25963729 PMID:27189055 PMID:27296223 PMID:27539358 PMID:30228064 PMID:32145629 PMID:32153214 PMID:32714078 PMID:34947998 PMID:35465754 PMID:35699857 PMID:35887390 PMID:35890622 PMID:38006930 | Bax | multiple interactions | EXP | | 6480464 | CTD | 18alpha-glycyrrhetinic acid inhibits the reaction [bisphenol A results in increased expression of BAX]; [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of BAX mRNA; Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of BAX protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of BAX mRNA]; Fluvastatin inhibits the reaction [bisphenol A results in increased expression of BAX protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased expression of BAX protein]]; Lycopene inhibits the reaction [bisphenol A results in increased expression of BAX mRNA]; taxifolin inhibits the reaction [bisphenol A results in increased expression of BAX protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased expression of BAX protein]] | PMID:25963729 PMID:27189055 PMID:32153214 PMID:35465754 PMID:35699857 PMID:36041667 | Bax | affects expression | ISO | Bax (Mus musculus) | 6480464 | CTD | bisphenol A affects the expression of BAX protein | PMID:33509759 | Bax | affects expression | ISO | BAX (Homo sapiens) | 6480464 | CTD | bisphenol A affects the expression of BAX mRNA; bisphenol A affects the expression of BAX protein | PMID:24156707 PMID:31916403 | Bax | decreases expression | ISO | Bax (Mus musculus) | 6480464 | CTD | bisphenol A results in decreased expression of BAX mRNA | PMID:29741722 | Bax | decreases expression | ISO | BAX (Homo sapiens) | 6480464 | CTD | bisphenol A results in decreased expression of BAX mRNA; bisphenol A results in decreased expression of BAX protein | PMID:15461258 PMID:21277958 PMID:23222814 PMID:24901218 | Bax | increases activity | ISO | Bax (Mus musculus) | 6480464 | CTD | bisphenol A results in increased activity of BAX protein | PMID:33485121 | Bax | increases expression | ISO | Bax (Mus musculus) | 6480464 | CTD | bisphenol A results in increased expression of BAX mRNA; bisphenol A results in increased expression of BAX protein | PMID:11906184 PMID:22269103 PMID:24458533 PMID:24905940 PMID:26512966 PMID:26746108 PMID:28393075 PMID:31201698 PMID:31263496 PMID:32407858 PMID:32488702 PMID:33485121 PMID:34186417 PMID:35219798 PMID:36858637 | Bax | increases expression | ISO | BAX (Homo sapiens) | 6480464 | CTD | bisphenol A results in increased expression of BAX mRNA; bisphenol A results in increased expression of BAX protein | PMID:30036487 PMID:33039870 PMID:34186270 PMID:34664771 PMID:35439536 PMID:37143426 | Bax | multiple interactions | ISO | Bax (Mus musculus) | 6480464 | CTD | 4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline inhibits the reaction [bisphenol A results in increased expression of BAX mRNA]; 4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [bisphenol A results in increased activity of BAX protein]; [Caffeine co-treated with bisphenol A] results in increased expression of BAX mRNA; Acetylcysteine inhibits the reaction [bisphenol A results in increased activity of BAX protein]; Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of BAX mRNA]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [bisphenol A results in increased activity of BAX protein]; coenzyme Q10 inhibits the reaction [bisphenol A results in increased expression of BAX mRNA]; Drugs, Chinese Herbal inhibits the reaction [bisphenol A results in increased expression of BAX protein]; Ginsenosides inhibits the reaction [bisphenol A results in increased expression of BAX protein]; KN 62 inhibits the reaction [bisphenol A results in increased expression of BAX protein]; U 0126 inhibits the reaction [bisphenol A results in increased expression of BAX protein]; VDAC1 promotes the reaction [bisphenol A results in increased expression of BAX protein]; W 7 inhibits the reaction [bisphenol A results in increased expression of BAX protein] | PMID:22269103 PMID:24905940 PMID:26512966 PMID:31756439 PMID:32488702 PMID:33485121 PMID:34186417 PMID:36858637 | Bax | multiple interactions | ISO | BAX (Homo sapiens) | 6480464 | CTD | [bisphenol A co-treated with 4-cumylphenol] results in decreased expression of BAX mRNA; [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of BAX mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of BAX mRNA; Curcumin inhibits the reaction [bisphenol A results in decreased expression of BAX protein]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of BAX protein] | PMID:23222814 PMID:28628672 PMID:31916403 PMID:35439536 PMID:36235125 | |
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