GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Kdm2a | decreases expression | ISO | Kdm2a (Rattus norvegicus) | 6480464 | CTD | bisphenol A results in decreased expression of KDM2A mRNA | PMID:26982218 | Kdm2a | increases expression | ISO | Kdm2a (Rattus norvegicus) | 6480464 | CTD | bisphenol A results in increased expression of KDM2A mRNA | PMID:25181051 PMID:30816183 | Kdm2a | increases expression | ISO | KDM2A (Homo sapiens) | 6480464 | CTD | bisphenol A results in increased expression of KDM2A mRNA; bisphenol A results in increased expression of KDM2A protein | PMID:37315367 | Kdm2a | increases methylation | ISO | Kdm2a (Rattus norvegicus) | 6480464 | CTD | bisphenol A results in increased methylation of KDM2A gene | PMID:28505145 | Kdm2a | multiple interactions | ISO | KDM2A (Homo sapiens) | 6480464 | CTD | [KDM2A protein co-treated with bisphenol A] results in decreased expression of and results in decreased activity of TET2 protein; [KDM2A protein co-treated with bisphenol A] results in decreased expression of TET2 mRNA; [KDM2A protein co-treated with bisphenol A] results in increased acetylation of ESR1 protein; [KDM2A protein co-treated with bisphenol A] results in increased phosphorylation of and results in decreased methylation of ESR1 protein; bisphenol A promotes the reaction [ESR1 protein binds to KDM2A protein]; bisphenol A promotes the reaction [KDM2A protein binds to TET2 promoter]; ESR1 protein affects the reaction [bisphenol A results in increased expression of KDM2A protein] | PMID:37315367 | | ||||||||||||||||||||||
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