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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1603405
Species: Homo sapiens
RGD Object: Gene
Symbol: ICMT
Name: isoprenylcysteine carboxyl methyltransferase
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ICMTmultiple interactionsEXP 6480464CTD[bisphenol A co-treated with Fulvestrant] results in decreased methylation of ICMT genePMID:31601247
ICMTdecreases expressionISOIcmt (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of ICMT mRNAPMID:25181051
ICMTdecreases methylationISOIcmt (Mus musculus)6480464CTDbisphenol A results in decreased methylation of ICMT promoterPMID:27312807
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