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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1562112
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Foxp3
Name: forkhead box P3
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Foxp3decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of FOXP3 mRNAPMID:25181051
Foxp3increases expressionEXP 6480464CTDbisphenol A results in increased expression of FOXP3 mRNAPMID:30816183 PMID:32528016
Foxp3increases methylationEXP 6480464CTDbisphenol A results in increased methylation of FOXP3 genePMID:28505145
Foxp3affects methylationISOFoxp3 (Mus musculus)6480464CTDbisphenol A affects the methylation of FOXP3 promoterPMID:27334623
Foxp3decreases expressionISOFoxp3 (Mus musculus)6480464CTDbisphenol A results in decreased expression of FOXP3 proteinPMID:35357751
Foxp3multiple interactionsISOFoxp3 (Mus musculus)6480464CTDbisphenol A inhibits the reaction [1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone inhibits the reaction [Ovalbumin results in decreased expression of FOXP3 mRNA]]; bisphenol A promotes the reaction [Ovalbumin results in decreased expression of FOXP3 mRNA]PMID:32964057 PMID:35533451
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