GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Xrcc6 | affects methylation | EXP | | 6480464 | CTD | bisphenol A affects the methylation of XRCC6 promoter | PMID:27334623 | Xrcc6 | multiple interactions | EXP | | 6480464 | CTD | [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of AGTR2 mRNA]; [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of AKR1B10 mRNA]; [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of AREG mRNA]; [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of ATF3 mRNA]; [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of CAR6 mRNA]; [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of CYP2D22 mRNA]; [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of DIO3 mRNA]; [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of FZD2 mRNA]; [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of GSTA5 mRNA]; [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of HP mRNA]; [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of IL18R1 mRNA]; [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of KAT2B mRNA]; [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of MMP15 mRNA]; [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of PRG4 mRNA]; [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of PTGS2 mRNA]; [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of ROBO3 mRNA]; [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of SLCO2B1 mRNA]; [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of TNS1 mRNA]; [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of CAR6 mRNA]; [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of CCL20 mRNA]; [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of CXCL3 mRNA]; [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of DSC1 mRNA]; [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of EGR4 mRNA]; [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of FRY mRNA]; [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of HCAR2 mRNA]; [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of HPGD mRNA]; [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of LCN2 mRNA]; [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of LGALS12 mRNA]; [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of MYH1 mRNA]; [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of MYH2 mRNA]; [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of NEBL mRNA]; [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of NPR3 mRNA]; [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of OSTN mRNA]; [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of PLCH2 mRNA]; [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of SAA3 mRNA]; [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of SLC26A7 mRNA]; [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of WFDC17 mRNA]; bisphenol A inhibits the reaction [[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] which results in increased expression of H2AX protein] | PMID:25693136 PMID:27082013 | Xrcc6 | affects expression | ISO | XRCC6 (Homo sapiens) | 6480464 | CTD | bisphenol A affects the expression of XRCC6 mRNA | PMID:30903817 | Xrcc6 | decreases expression | ISO | Xrcc6 (Rattus norvegicus) | 6480464 | CTD | bisphenol A results in decreased expression of XRCC6 mRNA | PMID:30816183 PMID:32528016 | Xrcc6 | decreases expression | ISO | XRCC6 (Homo sapiens) | 6480464 | CTD | bisphenol A results in decreased expression of XRCC6 protein | PMID:34186270 | Xrcc6 | increases expression | ISO | Xrcc6 (Rattus norvegicus) | 6480464 | CTD | bisphenol A results in increased expression of XRCC6 mRNA | PMID:25181051 PMID:27208089 | | ||||||||||||||||||||||
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