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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1550181
Species: Mus musculus
RGD Object: Gene
Symbol: Tubb3
Name: tubulin, beta 3 class III
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tubb3decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of TUBB3 mRNAPMID:30245210 PMID:32156529
Tubb3decreases methylationEXP 6480464CTDbisphenol A results in decreased methylation of TUBB3 promoterPMID:27312807
Tubb3decreases expressionISOTUBB3 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of TUBB3 mRNA; bisphenol A results in decreased expression of TUBB3 proteinPMID:27271280 PMID:29479338 PMID:35069845 PMID:37567409
Tubb3decreases expressionISOTubb3 (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of TUBB3 mRNAPMID:25381574 PMID:25963729
Tubb3increases expressionISOTubb3 (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of TUBB3 mRNAPMID:25181051
Tubb3multiple interactionsISOTUBB3 (Homo sapiens)6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TUBB3 mRNA; [Phenolsulfonphthalein deficiency co-treated with bisphenol A] results in increased expression of TUBB3 protein; IGF1 protein inhibits the reaction [bisphenol A results in decreased expression of TUBB3 mRNA]; IGF1 protein inhibits the reaction [bisphenol A results in decreased expression of TUBB3 protein]PMID:27271280 PMID:28628672 PMID:31629898
Tubb3multiple interactionsISOTubb3 (Rattus norvegicus)6480464CTDCurcumin inhibits the reaction [bisphenol A results in decreased expression of TUBB3 mRNA]PMID:25963729
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