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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1351719
Species: Homo sapiens
RGD Object: Gene
Symbol: TLX1
Name: T cell leukemia homeobox 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects methylationISORGD:15577166480464CTDbisphenol A affects the methylation of TLX1 promoter

PMID:27334623
decreases expressionISORGD:15636556480464CTDbisphenol A results in decreased expression of TLX1 mRNA

PMID:25181051
increases expressionISORGD:15577166480464CTDbisphenol A results in increased expression of TLX1 mRNA

PMID:30951980
multiple interactionsISORGD:15636556480464CTDbisphenol A inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of TLX1 mRNA]

PMID:18653720
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.