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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1349475
Species: Homo sapiens
RGD Object: Gene
Symbol: HSPA1A
Name: heat shock protein family A (Hsp70) member 1A
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HSPA1Aaffects expressionEXP 6480464CTDbisphenol A affects the expression of HSPA1A mRNAPMID:30903817
HSPA1Adecreases methylationEXP 6480464CTDbisphenol A results in decreased methylation of HSPA1A promoterPMID:30352284
HSPA1Amultiple interactionsEXP 6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of HSPA1A mRNAPMID:28628672
HSPA1Aaffects expressionISOHspa1a (Rattus norvegicus)6480464CTDbisphenol A affects the expression of HSPA1A mRNAPMID:30903817
HSPA1Adecreases expressionISOHspa1a (Mus musculus)6480464CTDbisphenol A results in decreased expression of HSPA1A mRNAPMID:26063408 PMID:37611474
HSPA1Aincreases expressionISOHspa1a (Mus musculus)6480464CTDbisphenol A results in increased expression of HSPA1A mRNA; bisphenol A results in increased expression of HSPA1A proteinPMID:12460799 PMID:33221593
HSPA1Aincreases expressionISOHspa1a (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of HSPA1A mRNAPMID:17010207
HSPA1Amultiple interactionsISOHspa1a (Rattus norvegicus)6480464CTD[bisphenol A co-treated with tributyltin] results in decreased expression of HSPA1A mRNAPMID:31129395
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