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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344636
Species: Homo sapiens
RGD Object: Gene
Symbol: SEC22A
Name: SEC22 homolog A, vesicle trafficking protein
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SEC22Adecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of SEC22A mRNA; bisphenol A results in decreased expression of SEC22A proteinPMID:29275510 PMID:33376534
SEC22Aincreases methylationEXP 6480464CTDbisphenol A results in increased methylation of SEC22A genePMID:31601247
SEC22Amultiple interactionsISOSec22a (Rattus norvegicus)6480464CTD[bisphenol A co-treated with Estradiol] results in decreased expression of SEC22A mRNAPMID:26496021
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